Ohio University

Cross section of brain vessel

Studying mammalian neurovascular development, physiology and pathophysiology

The Nielsen Lab

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About Research in the Nielsen Lab

Lab research interests include genetic regulation of mammalian neurovascular development, physiology and pathophysiology.

Interdependent development and functions of the mammalian nervous and vascular systems are tightly coordinated. The brain vasculature provides a critical and expansive blood supply to support neuronal metabolism and function, and vascular lesions within the brain are often accompanied by neurological dysfunction. Our lab is interested in understanding how these systems influence one another – e.g., how diverse neural and vascular cell populations respond to cues from one another. The lab currently studies neurovascular regulation in the context of brain arteriovenous malformation (AVM), a human vascular disease characterized by direct delivery of blood from artery to vein (without intervening capillaries), vessel entanglements, and often accompanied by neurological deficit. We are using genetic models of brain AVM to determine molecular and cellular mechanisms that regulate neurovascular development and function – and mechanisms involved in neurovascular pathogenesis – using mouse genetics, molecular and cell biological, and imaging approaches.

Photo of Cerebellum
Cerebellum

Recent News:

Nielsen Recognized as Honors Tutorial College Distinguished Mentor

From left, Dr. Corinne Nielsen and Samantha SelhorstWhen the Honors Tutorial College recognized outstanding mentorship at its May 3 graduate reception, one of four Distinguished Mentor awards went to Dr. Corinne Nielsen, Assistant Professor of Biological Sciences. Nielsen was nominated by Samantha Selhorst, a graduating HTC Neurosciences student, who completed senior thesis research in Nielsen’s lab. See […]

The post Nielsen Recognized as Honors Tutorial College Distinguished Mentor appeared first on Ohio University | College of Arts & Sciences.

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Posted on 05/14/2019

Selhorst Takes Top Honors with Outstanding Senior Thesis Award

Samantha Selhorst, portrait  Samantha Selhorst, an Honors Tutorial College senior in Neuroscience, received the top award for Outstanding Senior Thesis on May 3 at the HTC graduate reception. Her thesis is titled “Endothelial deletion of Rbpj leads to perivascular abnormalities in the brain.” Selhorst completed her senior thesis research in the laboratory […]

The post Selhorst Takes Top Honors with Outstanding Senior Thesis Award appeared first on Ohio University | College of Arts & Sciences.

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Posted on 05/14/2019

Nielsen Receives NIH Funding to Study Perivascular Cells in Brain

From left, Subhodip Adhicary (TBS graduate student), Samantha Selhorst (HTC Neuroscience student), Dr. Corinne Nielsen (Assistant Professor, Biological Sciences), shown at lab deskDr. Corinne Nielsen, Assistant Professor of Biological Sciences, received an R15 Academic Research Enhancement Award award from the National Institutes of Health. The R15 AREA supports projects that introduce undergraduate and graduate students to meritorious research; thus, a significant portion of the grant funds will support stipends, experimental allocations, and […]

The post Nielsen Receives NIH Funding to Study Perivascular Cells in Brain appeared first on Ohio University | College of Arts & Sciences.

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Posted on 05/14/2019

HTC Neuroscience Student Studies Underlying Pathology of Rare Brain Condition

HTC Neuroscience student Samantha Selhorst with Neuroscience Program Director Dr. Daewoo Lee at Neuroscience Research DayBy Amanda Biederman Rare diseases are often understudied, but Honors Tutorial College Neuroscience student Samantha Selhorst is working to characterize the pathology of arteriovenous malformation (AVM) under the direction of Biological Sciences professor Dr. Corinne Nielsen. Selhorst was recently awarded first prize for her thesis work in the undergraduate competition […]

The post HTC Neuroscience Student Studies Underlying Pathology of Rare Brain Condition appeared first on Ohio University | College of Arts & Sciences.

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Posted on 11/15/2018

Nielsen Gives Talk on How Cells are Impacted by Brain Arteriovenous Malformation

Dr. Corinne Nielsen, portraitDr. Corinne Nielsen, Assistant Professor of Biological Sciences, spoke at the national conference of the North American Vascular Biology Organization in Newport, RI, in October. Her talk was on “Effects on perivascular cells during Notch mediated brain arteriovenous malformation.” Abstract: Brain arteriovenous malformation (AVM) is a neurovascular disease characterized by […]

The post Nielsen Gives Talk on How Cells are Impacted by Brain Arteriovenous Malformation appeared first on Ohio University | College of Arts & Sciences.

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Posted on 10/31/2018

Neuroscience Research Day | Keynote on Tuning Auditory Cortex for Vocal Communication, Oct. 6

neuroscience illustration of neuronsOhio University neuroscientists will put their brains to work next month at the second Neuroscience Research Day. Neuroscience Research Day will take place Saturday, Oct. 6, from 8:30 a.m. to 5 p.m. at Lake Hope Lodge.  The event will include graduate and undergraduate poster competitions, presentations by OHIO faculty, and a […]

The post Neuroscience Research Day | Keynote on Tuning Auditory Cortex for Vocal Communication, Oct. 6 appeared first on Ohio University | College of Arts & Sciences.

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Posted on 10/01/2018

John J. Kopchick Awards Support 14 Student and Faculty Research Projects

2017 Kopchick Fellowship Awards Ceremony, candid shot of students and faculty  From Staff Reports Fourteen Ohio University students and faculty members received funding for their health and medical research from the John J. Kopchick Awards. The program will provide a total of $100,213 in grants and fellowships during its 2017-18 cycle to advance research on topics such as drug delivery, […]

The post John J. Kopchick Awards Support 14 Student and Faculty Research Projects appeared first on Ohio University | College of Arts & Sciences.

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Posted on 11/16/2017

Invited Speaker Brown Discusses Work on Axonal Transport at Neuroscience Research Day

Neuroscience AwardsBy Amanda Biederman The Ohio State University professor Anthony Brown opened the first annual Neuroscience Research Day with a keynote lecture describing his work on neurofilaments and axonal transport. Neuroscience Research Day, which was contrived by a team of faculty members, graduate students and undergraduate students, brought together members of […]

The post Invited Speaker Brown Discusses Work on Axonal Transport at Neuroscience Research Day appeared first on Ohio University | College of Arts & Sciences.

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Posted on 11/01/2017

Eight Arts & Sciences Faculty Awarded OHIO Research Seed Funds

Dr. Ashwini GaneshanCollege of Arts & Sciences faculty received seven out of 10 Ohio University Research Committee faculty awards for funding during its spring 2017 cycle. In total, the Ohio University Research Committee awarded $74,524. The program, which is funded by the Vice President for Research and Creative Activity, provides seed money […]

The post Eight Arts & Sciences Faculty Awarded OHIO Research Seed Funds appeared first on Ohio University | College of Arts & Sciences.

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Posted on 04/23/2017