Studying mammalian neurovascular development, physiology and pathophysiology
The Nielsen Lab
About Research in the Nielsen Lab
Lab research interests include genetic regulation of mammalian neurovascular development, physiology and pathophysiology.
Interdependent development and functions of the mammalian nervous and vascular systems are tightly coordinated. The brain vasculature provides a critical and expansive blood supply to support neuronal metabolism and function, and vascular lesions within the brain are often accompanied by neurological dysfunction. Our lab is interested in understanding how these systems influence one another – e.g., how diverse neural and vascular cell populations respond to cues from one another. The lab currently studies neurovascular regulation in the context of brain arteriovenous malformation (AVM), a human vascular disease characterized by direct delivery of blood from artery to vein (without intervening capillaries), vessel entanglements, and often accompanied by neurological deficit. We are using genetic models of brain AVM to determine molecular and cellular mechanisms that regulate neurovascular development and function – and mechanisms involved in neurovascular pathogenesis – using mouse genetics, molecular and cell biological, and imaging approaches.
Recent News:
Nielsen Recognized as Honors Tutorial College Distinguished Mentor
When the Honors Tutorial College recognized outstanding mentorship at its May 3 graduate reception, one of four Distinguished Mentor awards went to Dr. Corinne Nielsen, Assistant Professor of Biological Sciences. Nielsen was nominated by Samantha Selhorst, a graduating HTC Neurosciences student, who completed senior thesis research in Nielsen’s lab. See […]
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Read MoreSelhorst Takes Top Honors with Outstanding Senior Thesis Award
Samantha Selhorst, an Honors Tutorial College senior in Neuroscience, received the top award for Outstanding Senior Thesis on May 3 at the HTC graduate reception. Her thesis is titled “Endothelial deletion of Rbpj leads to perivascular abnormalities in the brain.” Selhorst completed her senior thesis research in the laboratory […]
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Read MoreNielsen Receives NIH Funding to Study Perivascular Cells in Brain
Dr. Corinne Nielsen, Assistant Professor of Biological Sciences, received an R15 Academic Research Enhancement Award award from the National Institutes of Health. The R15 AREA supports projects that introduce undergraduate and graduate students to meritorious research; thus, a significant portion of the grant funds will support stipends, experimental allocations, and […]
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Read MoreHTC Neuroscience Student Studies Underlying Pathology of Rare Brain Condition
By Amanda Biederman Rare diseases are often understudied, but Honors Tutorial College Neuroscience student Samantha Selhorst is working to characterize the pathology of arteriovenous malformation (AVM) under the direction of Biological Sciences professor Dr. Corinne Nielsen. Selhorst was recently awarded first prize for her thesis work in the undergraduate competition […]
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Read MoreNielsen Gives Talk on How Cells are Impacted by Brain Arteriovenous Malformation
Dr. Corinne Nielsen, Assistant Professor of Biological Sciences, spoke at the national conference of the North American Vascular Biology Organization in Newport, RI, in October. Her talk was on “Effects on perivascular cells during Notch mediated brain arteriovenous malformation.” Abstract: Brain arteriovenous malformation (AVM) is a neurovascular disease characterized by […]
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Read MoreNeuroscience Research Day | Keynote on Tuning Auditory Cortex for Vocal Communication, Oct. 6
Ohio University neuroscientists will put their brains to work next month at the second Neuroscience Research Day. Neuroscience Research Day will take place Saturday, Oct. 6, from 8:30 a.m. to 5 p.m. at Lake Hope Lodge. The event will include graduate and undergraduate poster competitions, presentations by OHIO faculty, and a […]
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Read MoreJohn J. Kopchick Awards Support 14 Student and Faculty Research Projects
From Staff Reports Fourteen Ohio University students and faculty members received funding for their health and medical research from the John J. Kopchick Awards. The program will provide a total of $100,213 in grants and fellowships during its 2017-18 cycle to advance research on topics such as drug delivery, […]
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Read MoreInvited Speaker Brown Discusses Work on Axonal Transport at Neuroscience Research Day
By Amanda Biederman The Ohio State University professor Anthony Brown opened the first annual Neuroscience Research Day with a keynote lecture describing his work on neurofilaments and axonal transport. Neuroscience Research Day, which was contrived by a team of faculty members, graduate students and undergraduate students, brought together members of […]
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Read MoreEight Arts & Sciences Faculty Awarded OHIO Research Seed Funds
College of Arts & Sciences faculty received seven out of 10 Ohio University Research Committee faculty awards for funding during its spring 2017 cycle. In total, the Ohio University Research Committee awarded $74,524. The program, which is funded by the Vice President for Research and Creative Activity, provides seed money […]
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